Part of the official UK Kennel Club testing scheme in Spaniel (English Springer)
Fucosidosis is a lysosomal storage disease which results from the enzyme alpha-L-fucosidosis being defective or absent. This results in the impaired breakdown, and therefore accumulation of complex sugars, primarily in cells of the nervous system. Unfortunately, the disease is progressive and fatal.
Affected dogs typically present with symptoms between the ages of 11 months and four years. Clinical signs observed include ataxia (wobbly gait), loss of balance, hearing problems, loss of learned behaviour, difficulty swallowing and weight loss.