Part of the official UK Kennel Club testing scheme in Staffordshire Bull Terrier
L-2-hydroxyglutaric aciduria (L-2-HGA) is a neurometabolic disorder. Affected dogs have increased levels of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid, and this substance is toxic to the cells of the central nervous system. L-2-HGA produces a variety of clinical neurological deficits, including “wobbly” gait, tremors, seizures, muscle stiffness with exercise or excitement and changes in behaviour. Affected dogs begin to show signs of disease from around four months of age, but it can also be later. There is no cure or treatment for L-2-HGA.
This test for the Staffordshire Bull Terrier L-2-HGA variant.