Golden Retriever Bundle

From: £72.96 Incl. VAT

Find out if your Golden Retriever could develop Progressive retinal atrophy at CAGT.

Select at least two tests from the selection below to build a bundle of your choice at discounted rates.

Degenerative Myelopathy

Important information about the relevance of this variant in most breeds.

CAGT have partnered with Laboklin to provide this test.

Ichthyosis (PNPLA1 type)

Part of the official UK Kennel Club testing scheme

Progressive Retinal Atrophy (PRA1 type)

Progressive Retinal Atrophy (PRA2 type)

Progressive Retinal Atrophy (PRCD type)

*Optigen Officially Licensed*

Von Willebrand Disease Type I

CODE GR_BUNDLE
Category
Turnaround 1-4 weeks
Breed(s) ,
Aliases

Overview

A number of test are available for the Golden Retriever and Labrador Retriever. Two or more of these tests purchased as part of this bundle will be discounted.

  1. Degenerative Myelopathy associated with the SOD1 gene
  2. Ichthyosis (PNPLA1 type) associated with the PNPLA1 gene
  3. Progressive retinal atrophy associated with the SLC4A3 gene (also known as PRA1)
  4. Progressive retinal atrophy associated with the TTC8 gene (also known as PRA2)
  5. Progressive retinal atrophy associated with the PRCD gene
  6. Von Willebrand Disease Type I associated with the VWD gene

Degenerative Myelopathy

Important: Degenerative Myelopathy is a rare disease that presents most commonly in German Shepherd Dogs and Boxers, sporadically in Pembroke Welsh Corgis, Cardigan Welsh Corgis, Bernese Mountain Dogs, Rhodesian Ridgebacks, Borzoi and Chesapeake Bay Retrievers. It is rarely diagnosed in other breeds or mixed-breed dogs. DM is considered genetically complex and will have more than one contributing genetic variant. The variant targeted by this test is widespread and found in more than 120 breeds. However, association of the variant with the disease has only been shown in very few breeds and should never be used to inform breeding decisions, except where close relatives have been clinically diagnosed.

Canine degenerative myelopathy (previously also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. Most dogs are at least 8 years old before clinical become apparent. DM usually starts with a muscle weakness, loss of muscle and loss of coordination (ataxia) in the hind limbs. Progression is generally quote slow, but dogs will eventually be crippled within approximately 3 years of the onset of disease.

Ichthyosis (PNPLA1 type)

Ichthyosis is a type of dermatitis (skin disease) caused by skin cells not working properly. This leads to large, different coloured scales on the skin. It is an inherited condition and has been found in many different breeds of dog, but they are not all caused by the same underlying genetic defect.
Ichthyosis in the Golden Retriever is recessive. Dermatological signs are visible from as young as a few weeks of age and include mild, moderate or severe scaling, initially with small white scales progressing to large blackish scales. There is no treatment for this disease, however, in some cases scale formation decreases in older dogs.

Progressive retinal atrophy (PRA)

Progressive retinal atrophy (PRA) is the most common form of inherited disease affecting the retina in dogs; the retina detects light and sends images to the brain. Progressive degeneration of the retina at the back of the eye is characteristic of PRA and leads to vision loss and blindness. PRA is not painful to dogs, and the first signs of the disease tend to be bumping in to objects, such as a piece of furniture that has been moved. Mutations in different genes cause genetically different forms of PRA. It affects many different breeds of dog, but each genetically distinct form usually affects one or a small number of breeds. At least two genetically distinct forms of progressive retinal atrophy are found in Golden Retrievers. Research suggests that there may be at least one form that has not yet been identified.

Progressive retinal atrophy (SLC4A3-type)

This specific form of PRA (also known as PRA1) is caused by a mutation in a gene called SLC4A3 and is indistinguishable from other forms of PRA in other breeds. The average age of onset of clinical signs is quite late, around 6 years, but can be variable.

Progressive retinal atrophy (TTC8-type)

A mutation in a gene called TTC8 causes this specific form of PRA (also known as PRA2). In humans TTC8 is also known as BBS8 and is associated with Bardet Biedl Syndrome and with non-syndromic Retinitis Pigmentosa. PRA is the primary feature in dogs homozygous with the mutation in TTC8, but they can also present with other characteristic such as obesity, renal anomalies, sperm defects and anosmia. The average age of onset of ophthalmic clinical signs is around 5 years, but can be variable.

Progressive retinal atrophy (PRCD type)

*Optigen Officially Licensed*
Progressive retinal atrophy (PRA) is the most common form of inherited disease affecting the retina in dogs. Genetically different forms of PRA, caused by mutations in different genes, affect many breeds of dog with each form usually affecting one or a small number of breeds. PRA is characterised by progressive degeneration of the retina at the back of the eye and leads to vision loss and blindness.
Progressive Rod Cone Degeneration (PRCD) is a form of PRA and was one of the first PRAs for which a genetic variant was identified. PRCD is different than most forms of PRA in that the variant has been found in a large number and diverse range of breeds.

Von Willebrand Disease Type I

Von Willebrand Disease (vWD) is an inherited bleeding disorder caused by lack of von Willebrand factor protein (vWF). This protein circulates in the blood stream and must be present at the site of blood vessel injury in order to control bleeding from that vessel. Clinical signs of vWD ranged from mild to severe bleeding tendency.
There are three forms of vWD (types 1, 2 and 3) that are defined by the quantity and structure of VWF in the blood plasma. Type 1 is characterised by a low concentration of vWF, but it has a normal structure and clinical severity of the disease is variable. These dogs are unlikely to bleed spontaneously but may be prone to excessive bleeding when undergoing surgery or in injured.