Golden Retriever Bundle

Find out if your Golden Retriever could develop Progressive retinal atrophy at CAGT.

Select at least two tests from the selection below to build a bundle of your choice at discounted rates.

Progressive Retinal Atrophy (PRA1 type)

Progressive Retinal Atrophy (PRA2 type)

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Overview

A number of test are available for the Golden Retriever and Labrador Retriever. Two or more of these tests purchased as part of this bundle will be discounted.

  1. Progressive retinal atrophy associated with the SLC4A3 gene (also known as PRA1)
  2. Progressive retinal atrophy associated with the TTC8 gene (also known as PRA2)

Progressive retinal atrophy (PRA)

Progressive retinal atrophy (PRA) is the most common form of inherited disease affecting the retina in dogs; the retina detects light and sends images to the brain. Progressive degeneration of the retina at the back of the eye is characteristic of PRA and leads to vision loss and blindness. PRA is not painful to dogs, and the first signs of the disease tend to be bumping in to objects, such as a piece of furniture that has been moved. Mutations in different genes cause genetically different forms of PRA. It affects many different breeds of dog, but each genetically distinct form usually affects one or a small number of breeds. At least two genetically distinct forms of progressive retinal atrophy are found in Golden Retrievers. Research suggests that there may be at least one form that has not yet been identified.

Progressive retinal atrophy (SLC4A3-type)

This specific form of PRA (also known as PRA1) is caused by a mutation in a gene called SLC4A3 and is indistinguishable from other forms of PRA in other breeds. The average age of onset of clinical signs is quite late, around 6 years, but can be variable.

Progressive retinal atrophy (TTC8-type)

A mutation in a gene called TTC8 causes this specific form of PRA (also known as PRA2). In humans TTC8 is also known as BBS8 and is associated with Bardet Biedl Syndrome and with non-syndromic Retinitis Pigmentosa. PRA is the primary feature in dogs homozygous with the mutation in TTC8, but they can also present with other characteristic such as obesity, renal anomalies, sperm defects and anosmia. The average age of onset of ophthalmic clinical signs is around 5 years, but can be variable.