A number of tests are available for the Miniature Schnauzer. Two or more of these tests purchased as part of this bundle will be discounted.
- Coagulation Factor VII Deficiency associated with the FVII gene
- Degenerative Myelopathy associated with the SOD1 gene
- Progressive Retinal Atrophy associated with the HIVEP3 gene
Coagulation Factor VII Deficiency
Coagulation Factor VII Deficiency is an inherited blood clotting disorder. Factor VII (F7) is a protein essential for blood clotting. A deficiency causes frequent nosebleeds, excessive bruising and excessive or prolonged bleeding after an injury or surgery. Affected dogs may not show clinical signs until they undergo surgery and excessive bleeding occurs.
Important: Degenerative Myelopathy is a rare disease that presents most commonly in German Shepherd Dogs and Boxers, sporadically in Pembroke Welsh Corgis, Cardigan Welsh Corgis, Bernese Mountain Dogs, Rhodesian Ridgebacks, Borzoi and Chesapeake Bay Retrievers. It is rarely diagnosed in other breeds or mixed-breed dogs. DM is considered genetically complex and will have more than one contributing genetic variant. The variant targeted by this test is widespread and found in more than 120 breeds. However, association of the variant with the disease has only been shown in very few breeds and should never be used to inform breeding decisions, except where close relatives have been clinically diagnosed.
Canine degenerative myelopathy (previously also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. Most dogs are at least 8 years old before clinical become apparent. DM usually starts with a muscle weakness, loss of muscle and loss of coordination (ataxia) in the hind limbs. Progression is generally quote slow, but dogs will eventually be crippled within approximately 3 years of the onset of disease.
Progressive Retinal Atrophy
Progressive retinal atrophy (PRA) is the most common form of inherited disease affecting the retina in dogs. Genetically different forms of PRA, caused by mutations in different genes, affect many breeds of dog with each form usually affecting one or a small number of breeds. PRA is characterised by progressive degeneration of the retina at the back of the eye and leads to vision loss and blindness.
An X-linked form of PRA (Type A PRA) was identified in the Miniature Schnauzer, but is very rare and doesn’t account for most cases of PRA. The more common PRA in the Miniature Schnauzer, Type B PRA detected by this test, is early onset with an average age at diagnosis of approximately 4 years. It is autosomal recessive and is characterised by abnormal development of the rod and cone photoreceptor cells of the retina, followed by a rapid progression of degeneration.