Shetland Sheepdog Bundle

Find out if your Shetland Sheepdog could develop Progressive retinal atrophy at CAGT.

Select at least two tests from the selection below to build a bundle of your choice at discounted rates.

Progressive Retinal Atrophy (BBS2 type)

Progressive Retinal Atrophy (CNGA1 type)



A number of test are available for the Shetland Sheepdog. Two or more of these tests purchased as part of this bundle will be discounted.

  1. Progressive retinal atrophy (BBS2-type)
  2. Progressive retinal atrophy (CNGA1-type)

Progressive retinal atrophy (PRA)

Progressive retinal atrophy (PRA) is the most common form of inherited disease affecting the retina in dogs; the retina detects light and sends images to the brain. Progressive degeneration of the retina at the back of the eye is characteristic of PRA and leads to vision loss and blindness. PRA is not painful to dogs, and the first signs of the disease tend to be bumping in to objects, such as a piece of furniture that has been moved. Mutations in different genes cause genetically different forms of PRA. It affects many different breeds of dog, but each genetically distinct form usually affects one or a small number of breeds. At least two genetically distinct forms of progressive retinal atrophy are found in Golden Retrievers. Research suggests that there may be at least one form that has not yet been identified.

Progressive retinal atrophy (BBS2-type)

A form of PRA in Shetland Sheepdogs is caused by a mutation in a gene called BBS2. In humans, mutations in BBS2 are associated with a condition known as Bardet Biedl syndrome.  This novel form of PRA, is unusual as it presents with other characteristics including a wavy, atypical textured coat, upturned nose and dental defects. There is evidence that this syndrome may also cause kidney abnormalities and obesity due to an enhanced motivation for food, but further studies are required to confirm this. The age of onset of this form of PRA is variable.

Progressive retinal atrophy (CNGA1-type)

This specific form of PRA is caused by a mutation in a gene called CNGA1 and is indistinguishable from other forms of PRA in other breeds. The average age of onset of clinical signs is around 5 years, but can be anything between 2 and 11 years