French Bulldog Bundle

From: £72.96 Incl. VAT

Find out if your French Bulldog could develop an inherited disease at CAGT.

Select at least two tests from the selection below to build a bundle of your choice at discounted rates.

Degenerative Myelopathy

Part of the official UK Kennel Club testing scheme

Important information about the relevance of this variant in most breeds.

Progressive Retinal Atrophy (CORD1 type)

Hereditary Cataract (Staffordshire Bull Terrier type)

Part of the official UK Kennel Club testing scheme

Chondrodystrophy (CDDY) with risk of Intervertebral Disc Disease and Chondrodysplasia (CDPA)

CODE FBD_BUNDLE
Category
Turnaround 1-4 weeks
Breed(s)
Aliases

Overview

A number of tests are available for the French Bulldog. Two or more of these tests purchased as part of this bundle will be discounted.

  1. Chondrodysplasia (CDPA) associated with the FGF4 -18 retrogene insertion
  2. Chondrodystrophy (CDDY) with risk of IVDD associated with the FGF4-12 retrogene insertion.
  3. Degenerative Myelopathy associated with the SOD1 gene
  4. Hereditary Cataract (Staffordshire Bull Terrier type) associated with the HSF4 gene
  5. Progressive Retinal Atrophy associated with the CORD1 gene

Chondrodysplasia (CDPA)

Chondrodysplasia (CDPA) is shortened long bones, resulting in dogs with short legs.

A partial copy of the FGF4 gene has been inserted (FGF4-18, a retrogene insertion) on chromosome 18 and is associated with CDPA. Evidence that suggests that any dog with one or two copies of FGF4-18 will have short legs. Unlike CDDY, CDPA is not associated with any disease.

Chondrodystrophy (CDDY) with risk of IVDD

Chondrodystrophy (CDDY) in dogs is defined by dysplastic (abnormal), shorted long bones (short legs) and premature degeneration and calcification of intervertebral discs. Chondrodystrophic breeds are prone to a type of disc degeneration called chondroid metaplasia, where the discs become hardened and less able to flex with movement and therefore more prone to bulging or rupture i.e. Intervertebral Disk Disease (IVDD). The calcified inner disc material also puts pressure on the spinal cord, causing pain and damage to the nerves running through the spinal cord. Dogs may suffer from severe pain, inability to urinate or defecate, paralysis and even death. Many affected dogs are treated by surgically removing the prolapsed disc.

A partial copy of the FGF4 gene has been inserted (FGF4-12, a retrogene insertion) on chromosome 12 and is associated with CDDY. Evidence that suggests that any dog with one or two copies of FGF4-12 will be affected with CDDY, will have short legs and will be predisposed to IVDD. However, not all dogs with FGF4-12 will go on to develop IVDD.

Degenerative Myelopathy

Important: Degenerative Myelopathy is a rare disease that presents most commonly in German Shepherd Dogs and Boxers, sporadically in Pembroke Welsh Corgis, Cardigan Welsh Corgis, Bernese Mountain Dogs, Rhodesian Ridgebacks, Borzoi and Chesapeake Bay Retrievers. It is rarely diagnosed in other breeds or mixed-breed dogs. DM is considered genetically complex and will have more than one contributing genetic variant. The variant targeted by this test is widespread and found in more than 120 breeds. However, association of the variant with the disease has only been shown in very few breeds and should never be used to inform breeding decisions, except where close relatives have been clinically diagnosed.

Canine degenerative myelopathy (previously also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. Most dogs are at least 8 years old before clinical become apparent. DM usually starts with a muscle weakness, loss of muscle and loss of coordination (ataxia) in the hind limbs. Progression is generally quote slow, but dogs will eventually be crippled within approximately 3 years of the onset of disease.

Hereditary Cataract (Staffordshire Bull Terrier type) (HSF4)

Cataracts are a leading form of blindness in the dog. Cataracts associated with an HSF4 insertion appear early in life, within the first few weeks or months of life. The cataracts will progress to total blindness by 2-3 years of age and the only effective treatment is a surgical intervention.

Progressive Retinal Atrophy (CORD1)

Progressive retinal atrophy (PRA) is the most common form of inherited disease affecting the retina in dogs. Genetically different forms of PRA, caused by mutations in different genes, affect many breeds of dog with each form usually affecting one or a small number of breeds. PRA is characterised by progressive degeneration of the retina at the back of the eye and leads to vision loss and blindness.

In most knowns forms of PRA the rod cells of the retina degenerate first, resulting in a loss of dim light vision initially. In this specific form of PRA the cone cells of the retina degenerate first, followed by the rod cells (cone rod dystrophy), so dogs affected with CORD1 do not develop night blindless first. As with all dogs suffering from PRA, there is no cure. Dogs generally adapt quite well to blindness – especially when it develops gradually – as long as their surroundings remain familiar (e.g. furniture does not get rearranged, they do not move house etc).

The age of onset of CORD1 is highly variable. Dogs the are also homozygous for the MAP9 modifier mutation will develop the disease from a young age (< 3 years old). On the other hand, dogs that are homozygous for the CORD1-RPGRIP1 variant but not the MAP9 variant may develop the disease later in life (> 6 years old).