Tibetan Terrier Bundle

Find out if your Tibetan Terrier could develop an inherited disease at CAGT.

Select at least two tests from the selection below to build a bundle of your choice at discounted rates.

Primary Lens Luxation

Neuronal Ceroid Lipofuscinosis (Tibetan Terrier type)

Progressive Retinal Atrophy (RCD4 type)

Progressive Retinal Atrophy (PRA3 type)

CODE TT_BUNDLE
Category
Breed(s)
Aliases

Overview

A number of tests are available for Tibetan Terriers. Two or more of these tests purchased as part of this bundle will be discounted.

  1. Primary Lens Luxation
  2. Neuronal Ceroid Lipofuscinosis (Tibetan Terrier type)
  3. Progressive retinal atrophy (RCD4 type)
  4. Progressive Retinal Atrophy associated with the FAM161A gene

Primary Lens Luxation

Primary lens luxation (PLL) is a painful and potentially blinding inherited eye disease. It typically affects dogs between 3 and 8 years of age and in many breeds is caused by a single nucleotide substitution in the ADAMTS17 gene.

Neuronal Ceroid Lipofuscinosis (Tibetan Terrier type)

Neuronal ceroid lipofuscinosis (NCL) is a progressive neurodegenerative disease characterised by brain and retinal atrophy. The lipopygment lipofuscin builds up in the neural cells and some organs, such as liver, spleen, kidneys etc. This storage causes neuronal loss, cortical atrophy, and cerebellar and retinal degeneration. The result is seizures, progressive deterioration of cognition (dementia), motor function impairment (involuntary movements, myoclonus, ataxia, spasticity) and blindness. NCL in Tibetan Terriers is caused by the ATP13A2 gene and has a late age of onset, appearing at 5-7 years.

Progressive retinal atrophy (RCD4 type)

Progressive retinal atrophy (PRA) is the most common form of inherited disease affecting the retina in dogs; the retina detects light and sends images to the brain. Progressive degeneration of the retina at the back of the eye is characteristic of PRA. This degeneration leads to vision loss and blindness, but is not painful to dogs. The first signs of the disease tend to be bumping in to objects, such as a piece of furniture that has been moved. Mutations in different genes cause genetically different forms of PRA. It affects many different breeds of dog , but each genetically distinct form usually affects one or a small number of breeds. This form of progressive retinal atrophy in the Tibetan Terrier is caused by the same mutation in a gene called PCARE (previously known as C2ORF71) that was originally described in Gordon Setters.

Progressive Retinal Atrophy (FAM161A-type)

This form of progressive retinal atrophy in the Tibetan Terrier is caused by the same mutation in a gene called FAM161A that was originally described in Tibetan Spaniels.