Staffordshire Bull Terrier Bundle

Find out if your Staffordshire Bull Terrier could develop an inherited disease at CAGT.

Hereditary Cataract (Staffordshire Bull Terrier type)

L-2-Hyroxyglutaric Aciduria



A number of tests are available for the Staffordshire Bull Terrier. Two or more of these tests purchased as part of this bundle will be discounted.

  1. L-2-hydroxyglutaric aciduria associated with the L2HGDH gene
  2. Hereditary Cataract associated with the HSF4 gene

L-2-hydroxyglutaric aciduria

L-2-hydroxyglutaric aciduria (L-2-HGA) is a neurometabolic disorder. Affected dogs have increased levels of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid, and this substance is toxic to the cells of the central nervous system. L-2-HGA produces a variety of clinical neurological deficits, including “wobbly” gait, tremors, seizures, muscle stiffness with exercise or excitement and changes in behaviour. Affected dogs begin to show signs of disease from around four months of age, but it can also be later. There is no cure or treatment for L-2-HGA.

Hereditary Cataract

Cataracts are a leading form of blindness in the dog. Cataracts associated with an HSF4 insertion appear early in life, within the first few weeks or months of life. The cataracts will progress to total blindness by 2-3 years of age and the only effective treatment is a surgical intervention.