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Cavador Bundle

From: Original price was: £96.00.Current price is: £72.96. Incl. VAT

Find out if your Cavador could develop an inherited disease at CAGT.

Select at least two tests from the selection below to build a bundle of your choice at discounted rates.

Curly Coat Dry Eye Syndrome

Degenerative Myelopathy

Important information about the relevance of this variant in most breeds.

CAGT have partnered with Laboklin to provide this test.

Episodic Falling

Macular Corneal Dystrophy

Obesity and food motivation

Progressive Retinal Atrophy (PRCD type)

*Optigen Officially Licensed*

Stargardt Disease

Exercise Induced Collapse (Retriever Type)

CAGT have partnered with Laboklin to provide this test.

CODE CKCS-LR_BUNDLE
Category
Turnaround 1-4 weeks
Breed(s)
Aliases

Overview

A number of test are available for the Cavador. Two or more of these tests purchased as part of this bundle will be discounted.

  1. Curly Coat Dry Eye Syndrome associated with the FAM83H gene
  2. Degenerative Myelopathy associated with the SOD1 gene
  3. Episodic Falling associated with the BCAN gene
  4. Exercise Induced Collapse associated with the DNM1 gene
  5. Macular Corneal Dystrophy associated with the CHST6 gene
  6. Obesity and food motivation associated with the POMC gene
  7. Progressive Retinal Atrophy (PRCD type) associated with the PRCD gene
  8. Stargardt Disease associated with the ABCA4 gene

Curly Coat Dry Eye Syndrome

Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis (CKCSID) is more commonly referred to as ‘‘curly coat dry eye syndrome’’. The disease is congenital; puppies are born with an abnormally rough/curly coat and are usually smaller than littermates. Affected dogs have reduced production of aqueous tears (keratoconjuncitivits sicca commonly called “dry eye”), a tacky mucoid discharge around their eyes and ulceration of the cornea in severe cases. They also have persistent scaling of the skin (ichthyosiform dermatosis) causing them to scratch.

The disease is progressive and beings to affect footpads and teeth. It is difficult to manage, and many owners choose to euthanise affected dog’s due poor quality of life.

Degenerative Myelopathy

Important: Degenerative Myelopathy is a rare disease that presents most commonly in German Shepherd Dogs and Boxers, sporadically in Pembroke Welsh Corgis, Cardigan Welsh Corgis, Bernese Mountain Dogs, Rhodesian Ridgebacks, Borzoi and Chesapeake Bay Retrievers. It is rarely diagnosed in other breeds or mixed-breed dogs. DM is considered genetically complex and will have more than one contributing genetic variant. The variant targeted by this test is widespread and found in more than 120 breeds. However, association of the variant with the disease has only been shown in very few breeds and should never be used to inform breeding decisions, except where close relatives have been clinically diagnosed.

Canine degenerative myelopathy (previously also known as chronic degenerative radiculomyelopathy) is a progressive disease of the spinal cord in older dogs. Most dogs are at least 8 years old before clinical become apparent. DM usually starts with a muscle weakness, loss of muscle and loss of coordination (ataxia) in the hind limbs. Progression is generally quote slow, but dogs will eventually be crippled within approximately 3 years of the onset of disease.

Episodic Falling

Episodic Falling (EF) is a paroxysmal exertion-induced dyskinesia. It is usually exercise, excitement or stress-induced and episodes begin between three to seven months of age. EF is a disorder of the muscles that causes increased muscle tone and muscle spasticity (especially those of the limbs) resulting in limbs that appear “locked” in an extended position and dogs are unable to relax their muscles. This muscle spasticity results in a characteristic “praying” position and/or collapse. Episodes can last from a few seconds to a few minutes, and dogs appear fully conscious throughout.

Exercise Induced Collapse

Exercise Induced Collapse (EIC) is an inherited condition that primarily affects Labrador Retrievers and their related breeds – mainly Labrador crosses. The variant responsible has also been found in other breeds, including Curly-coated Retrievers, Boykin spaniels and Pembroke Welsh Corgis. The signs of EIC typically become noticeable when dogs undergo rigorous training. The initial symptoms usually manifest between the ages of 5 months and 3 years, although there have been cases where affected dogs didn’t experience collapse episodes until as late as age 10. Dogs with this condition can tolerate mild to moderate exercise, but after engaging in heavy exercise for a duration of 5 to 20 minutes, they experience weakness and collapse. While some dogs may only exhibit collapse episodes sporadically, severely affected dogs can collapse whenever they are exercised to this extent. The condition can be exacerbated by excitement and high temperatures.

Macular Corneal Dystrophy

Macular Corneal Dystrophy is an inherited and progressive eye disease. Initial clinical signs are cloudy corneas and/or visual impairment, first observed between four and six years of age. In addition, white/grey opacities are also observed. The cloudiness and opacities are caused by an abnormal accumulation of glycosaminoglycans in the cornea.

MCD is progressive; as the density of the corneal haze increases, increased vascularization is observed and vision is increasingly impaired.

Obesity and food motivation

In developed countries the rate of canine obesity ranges between 34% and 59%. Obesity is associated with reduced lifespan and several other comorbidities, as it is in humans. Labrador retrievers have among the highest prevalence of obesity and are particularly food motivated. The POMC gene is known to be important in regulating how the brain recognises hunger and the feeling of being full after a meal. A variant in the pro-opiomelanocortin (POMC) gene has been associated with increased body weight, adiposity (body fat) and food motivation in Labrador and Flat-coat retrievers.
The variant identified is relatively common with an allele frequency of 12% in labrador retrievers. Interestingly a higher frequency of 45% was observed in assistance dog populations.

Progressive Retinal Atrophy (PRCD type)

*Optigen Officially Licensed*
Progressive retinal atrophy (PRA) is the most common form of inherited disease affecting the retina in dogs. Genetically different forms of PRA, caused by mutations in different genes, affect many breeds of dog with each form usually affecting one or a small number of breeds. PRA is characterised by progressive degeneration of the retina at the back of the eye and leads to vision loss and blindness.
Progressive Rod Cone Degeneration (PRCD) is a form of PRA and was one of the first PRAs for which a genetic variant was identified. PRCD is different than most forms of PRA in that the variant has been found in a large number and diverse range of breeds.

Stargardt Disease

Stargardt disease is an inherited eye disease that affects dogs, primarily Labrador Retrievers. Onset of significant clinical signs is late in life, with affected dogs presenting with observable visual problems around 10 years of age. As with other retinal degenerations, such as progressive retinal atrophy, Stargardt disease is characterised by the degeneration of the rod and cone photoreceptor cells of the retina. Dog therefore experience visual deficits in bright and low light conditions. It is a progressive disease and symptoms will get worse as the dog ages.